Lewis and his nerdy friends attend Booger's wedding to the daughter of a rich Republican, but nerd-haters in the family do everything possible to prevent the wedding going ahead. Meanwhile, Lewis awaits with eagerness the birth of his unborn foetal child...

The third movie in the Nerds series: The nerds are now in control of the university, as a result of Lewis Skolnick and the rest's actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won't reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.